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About Theoretical Biology and Medical Modelling

This page includes information about the aims and scope of Theoretical Biology and Medical Modelling, editorial policies, open access and article-processing charges, the peer review process and other information. For details of how to prepare and submit a manuscript through the online submission system, please see the instructions for authors.

Aims & scope

Theoretical Biology and Medical Modelling (TBioMed) is an open access, peer-reviewed, online journal adopting a broad definition of "biology" and focusing on theoretical ideas and models associated with developments in biology and medicine.

Mathematicians, biologists and clinicians of various specialisms, philosophers and historians of science are all contributing to the emergence of novel concepts in an age of systems biology, bioinformatics and computer modelling. This is the field in which TBioMed operates. We welcome submissions that are technically sound and offering either improved understanding in biology and medicine or progress in theory or method.

Theoretical issues have become as topical as any other research activity and TBioMed offers the efficient, high-quality peer-review service that is needed to allow the timely dissemination of research. Being an open access publication, the journal reaches the widest possible audience. Comments from reviewers and other interested readers can be posted online to encourage debate, creating an ideal forum for communication of theoretical work.

Open access

All articles published by Theoretical Biology and Medical Modelling are made freely and permanently accessible online immediately upon publication, without subscription charges or registration barriers. Further information about open access can be found here.

Authors of articles published in Theoretical Biology and Medical Modelling are the copyright holders of their articles and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the article, according to the BioMed Central copyright and license agreement.

For authors who are US government employees or are prevented from being copyright holders for similar reasons, BioMed Central can accommodate non-standard copyright lines. Please contact us if further information is needed.

Article-processing charges

Open access publishing is not without costs. Theoretical Biology and Medical Modelling therefore levies an article-processing charge of £1370/$2145/€1745 for each article accepted for publication. If the corresponding author's institution is a Member, the cost of the article-processing charge is covered by the membership, and no further charge is payable. In the case of authors whose institutions are Supporter Members, however, a discounted article-processing charge is payable by the author. We routinely waive charges for authors from low-income countries. For other countries, article-processing charge waivers or discounts are granted on a case-by-case basis to authors with insufficient funds. Authors can request a waiver or discount during the submission process. For further details, see our article-processing charge page.

Indexing services

All articles published in Theoretical Biology and Medical Modelling are included in:

  • Biological Abstracts
  • CAS
  • Citebase
  • DOAJ
  • Embase
  • EmBiology
  • Google Scholar
  • OAIster
  • PubMed
  • PubMed Central
  • Science Citation Index Expanded
  • SCImago
  • Scopus
  • Zetoc

The full text of all research articles is deposited in digital archives including e-Depot (The Netherlands).

The full text of all research articles published by BioMed Central is also available on SpringerLink.

Theoretical Biology and Medical Modelling is tracked by Thomson Reuters (ISI) and has an Impact Factor of 0.95.

Publication and peer review process

Content overview

Theoretical Biology and Medical Modelling considers the following types of articles:

  • Research - reports of original theoretical and modelling work.
  • Reviews - Key aims of reviews are to provide systematic and substantial coverage of mature subjects, evaluations of progress in specified areas, and/or assessments of emerging technologies. Review articles should have a fresh and critical view of the topic and opinions should be qualified with references to original research articles.
  • Commentaries - short, focused and opinionated articles on any subject within the scope of TBioMed; these articles are usually related to a contemporary issue, such as recent research findings. Effective from July 2013, we no longer consider unsolicited Commentary articles. All Commentaries are solicited by editors.
  • Database articles - descriptions of a new database or a substantial improvement of an existing database.
  • Software articles - descriptions of newly developed software tools or substantial improvements to existing tools that are specifically related to modelling.


Peer-review policies

TBioMed publishes articles on aspects of theoretical biology or medical modelling that are judged acceptable by strong peer review. Manuscripts need not be explicitly mathematical, although we of course welcome rigorous mathematical proofs. Preference will be given to work that aims to explain rather than simply describe experimental or observational data.


  • TBioMed operates a closed peer-review system. Manuscripts are initially screened by the Editors-in-Chief and suitable manuscripts are sent to at least two reviewers for consideration. Decisions will be made on the recommendations of the reviewers, but final decisions lie with the Editors-in-Chief.

Edited by Hiroshi Nishiura, Edward Rietman and Rongling Wu, Theoretical Biology and Medical Modelling is supported by an expert Editorial Board.


Authors will be able to check the progress of their manuscript through the submission system at any time by logging into My Theoretical Biology and Medical Modelling, a personalized section of the site.


High-quality, bound reprints can be purchased for all articles published. Please see our reprints website for further information about ordering reprints.


Theoretical Biology and Medical Modelling will consider supplements based on proceedings (full articles or meeting abstracts), reviews or research. All articles submitted for publication in supplements are subject to peer review. Published supplements are fully searchable and freely accessible online and can also be produced in print. For further information, please contact us.

Editorial policies

All manuscripts submitted to TBioMed should adhere to BioMed Central's editorial policies.

Citing articles in Theoretical Biology and Medical Modelling

Articles in Theoretical Biology and Medical Modelling should be cited in the same way as articles in a traditional journal. Because articles are not printed, they do not have page numbers; instead, they are given a unique article number.

Article citations follow this format:

Authors: Title. Theor Biol Med Model [year], [volume number]:[article number].

e.g. Roberts LD, Hassall DG, Winegar DA, Haselden JN, Nicholls AW, Griffin JL: Increased hepatic oxidative metabolism distinguishes the action of Peroxisome Proliferator-Activated Receptor delta from Peroxisome Proliferator-Activated Receptor gamma in the Ob/Ob mouse. Theor Biol Med Model 2009, 1:115.

refers to article 115 from Volume 1 of the journal.

Why publish your article in Theoretical Biology and Medical Modelling?

High visibility

Theoretical Biology and Medical Modelling's open access policy allows maximum visibility of articles published in the journal as they are available to a wide, global audience. Articles that have been especially highly accessed are highlighted with a 'Highly accessed' graphic, which appears on the journal's contents pages and search results.

Speed of publication

Theoretical Biology and Medical Modelling offers a fast publication schedule whilst maintaining rigorous peer review; all articles must be submitted online, and peer review is managed fully electronically (articles are distributed in PDF form, which is automatically generated from the submitted files). Articles will be published with their final citation after acceptance, in both fully browsable web form, and as a formatted PDF; the article will then be available through Theoretical Biology and Medical Modelling and BioMed Central.


Online publication in Theoretical Biology and Medical Modelling gives authors the opportunity to publish large datasets, large numbers of color illustrations and moving pictures, to display data in a form that can be read directly by other software packages so as to allow readers to manipulate the data for themselves, and to create all relevant links (for example, to PubMed, to sequence and other databases, and to other articles).

Promotion and press coverage

Articles published in Theoretical Biology and Medical Modelling are included in article alerts and regular email updates. Some may be included in abstract books mailed to academics and are highlighted on Theoretical Biology and Medical Modelling's pages and on the BioMed Central homepage.

In addition, articles published in Theoretical Biology and Medical Modelling may be promoted by press releases to the general or scientific press. These activities increase the exposure and number of accesses for articles published in Theoretical Biology and Medical Modelling. A list of articles recently press-released by journals published by BioMed Central is available here.

Authors of articles published in Theoretical Biology and Medical Modelling retain the copyright of their articles and are free to reproduce and disseminate their work (for further details, see the BioMed Central copyright policy and license agreement).

For further information about the advantages of publishing in a journal from BioMed Central, please click here.