Table 1

Summary of predicted tyrosine phosphorylation sites.
Sitea
 NetPhosb
 Scansitec
 2Dd
 Surface Accessibilitye

MYH1
 MYH4
 MYH2
 MYH8
 MYSS_CHICK
 MYH3_CHICK
 MYH3
 MYH1
 MYH4
 MYH2
 MYH8
 MYSS_CHICK
 MYH3_CHICK
 MYH3
 MYH1
 1BR2
 1B7T:A
 2MYS: A
 Mean
47
 -
 -
 -
 Y


-
 -
 -



E(4)
 (14.5)
 (21)
 (16)
 18.5
54
 -
 -
 -
 -
 -
 -
 Y
 -
 -
 -
 -
 -
 -
E(7)
(52)
 (60)
 56.0
85
 Y
 Y
 Y
 Y
 Y
 Y
 Y






C(2)
 (34.7)
 (28)
 16
 26.2
163
 Y
 Y
 Y
 Y
 Y
 Y
 Y
 YP
 YP
 YP
 YP
 YP
 YP
 YP
 H(9)
 13.3
 47
 8
 22.8
286
 Y
 Y
 Y
 Y
 Y
 Y
 Y

Y
 Y


H(7)
 (0)
 0
 0
 0.0
313
 Y
 -




YP
 -
 Y
 Y
 YP
 Y
 Y
 C(4)
 7
 5
 8
 6.7
413
 Y
 Y
 Y
 Y
 -
 Y
 Y



-

E(7)

(68)
 68.0
435




-
 Y




-
H(9)
 (0.7)
 4
 3
 2.6
504
 Y
 Y
 Y
 Y
 Y
 Y
 Y






H(9)
 0
 6
 9
 5.0
719
 Y
 Y
 Y
 Y
 Y

YP
 YP
 YP
 YP
 YP
 YP
 Y
 H(6)
 (21.8)
 19
 9
 16.6
1379
 Y
 Y
 Y
 Y
 Y
 Y
 Y






H(6)



1464
 -
 Y
 -
 Y
 Y
 Y
 -
 -
-


-
 H(7)



1492
 Y
 Y
 Y
 Y
 Y
 Y
 Y


YP

P
 H(6)



1856
 Y
 Y
 Y
 Y
 Y
 Y
 Y
 Y
 Y
 Y
 Y
 Y
 Y
 Y
 H(4)



a. Sites are numbered relative to the MHC sequence MYH1_HUMAN/P12882.

b. Y indicates predicted tyrosine phosphorylation site in all the sequences of orthologous group, with a score of ≥ 0.8 in at least one human sequence. Dashes indicate lack of a tyrosine in that position.

c. Y indicates predicted tyrosine phosphorylation site in all the sequences of orthologous group on 'Low Stringency'. P indicates predicted phosphotyrosine recognition site in all the sequences of orthologous group on 'Low Stringency'. Dashes indicate lack of a tyrosine in that position.

d. PSIPRED (McGuffin, Bryson and Jones 2000) secondary structure position for MYH1_HUMAN. Letters indicate predicted secondary structure (H = helix, E = strand, C = coil). Numbers in brackets are confidence measures (0 = low, 9 = high).

e. Surface accessibility figures are "numbers of water molecules in contact with this residue *10, or residue water exposed surface in Angstrom**2" (Kabsch and Sander 1983). Missing values indicate residues missing from the PDB structure. Values in brackets indicate residues that are not tyrosines in the PDB structure.

Harney et al. Theoretical Biology and Medical Modelling 2005 2:12   doi:10.1186/1742-4682-2-12