Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b

Trevor G Marshall¹ , Robert E Lee² and Frances E Marshall³

¹Autoimmunity Research Foundation, Thousand Oaks, California 91360, USA

²Black Hawk College, Moline, Illinois 61443, USA

³Los Robles Regional Medical Centre, Thousand Oaks, California 91360, USA

author email corresponding author email

Theoretical Biology and Medical Modelling 2006, 3:1doi:10.1186/1742-4682-3-1


Published:	10 January 2006

Additional files

Additional File 1:

'ARB-immune-models.tar.gz' – Models of receptors and significant ligands. This is a Tar-Gzip archive which can by unpacked by using 'tar-xvzf', Winzipv8+ or 'Mac Stuffit'. There are five directories within it, containing a total of 35 files, 1.54 Meg when unpacked, 360 K when compressed: • 'AT2R1' contains the receptor model described in this paper, plus the docked conformation of each ARB, corresponding to the Ki values in Table 1. • 'CCR2b' contains the receptor model we derived from 1KP1, together with TAK779 and each of the ARBs in their docked conformation. • 'PPAR' contains the receptor model we derived from PDB:1FM9 together with the GI262570 ligand from PDB:1FM9 and each of the ARBs which have low Ki values when docked with the receptor. • 'VDR_from_1DB1" contains the VDR model we derived from PDB:1DB1 along with the docked conformations of the ARBs, 1,25-D (from PDB:1DB1) and TX522 (from PDB:1TXI). • 'VDR_from_1TXI' contains the VDR model we derived from PDB:1TXI along with the docked conformation of TX522, 1,25-D and Telmisartan.

Format: GZ Size: 361KB Download file