Figure 1.

Amino acid co-locations vs. size, charge, and hydrophobe compatibility indexes. Average propensity of the 400 different amino acid co-locations in 80 different protein structures (SeqX 80) are plotted against size, charge and hydrophobe compatibility indexes (SCI, CCI, HCI). The original "row" values are indicated in (A-C). The SeqX 80 values were corrected by the co-location values, which are expected only by chance in proteins where the amino acid frequency follows the natural codon frequency (NF) (D-F).