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Alternative spliced genes selected by our method: Comparison of non-metastatic medulloblastomas with metastatic medulloblastomas |
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| Affymetrix Probe Set ID |
Gene Symbol |
Number of Affymetrix Probes in the Predicted Pseudo-exon |
Nucleotide Positions of Predicted Pseudo-exon in the Gene |
Mean Difference |
Standard Error |
Z-score |
Description of the Genes |
|
|
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| M81882_at |
GAD2 |
4 |
(2135–2285) |
-1.28 |
0.20 |
-6.45 |
glutamate decarboxylase 2 (pancreatic islets and brain, 65 kDa) |
| M13955_at |
KRT7 |
5 |
(1402–1474) |
-0.63 |
0.12 |
-5.23 |
keratin 7 |
| U17327_at |
NOS1 |
7 |
(6805–7003) |
-0.66 |
0.13 |
-5.19 |
nitric oxide synthase 1 (neuronal) |
| X14329_at |
CPN1 |
4 |
(1569–1665) |
-0.62 |
0.12 |
-5.18 |
carboxypeptidase N, polypeptide 1, 50 kD |
| M89470_s_at |
PAX2 |
6 |
(2855–2972) |
-0.92 |
0.19 |
-4.91 |
paired box gene 2 |
| L14542_at |
KLRC3 |
5 |
(916–1006) |
-1.18 |
0.24 |
-4.91 |
killer cell lectin-like receptor subfamily C, member 3 |
| X76648_at |
GLRX |
3 |
(704–776) |
-1.35 |
0.28 |
-4.86 |
glutaredoxin (thioltransferase) |
|
|
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| U82987_at |
BBC3 |
3 |
(1578–1638) |
2.25 |
0.32 |
6.98 |
BCL2 binding component 3 |
| U01102_at |
SCGB1A1 |
2 |
(409–439) |
1.42 |
0.25 |
5.62 |
secretoglobin, family 1A, member 1 (uteroglobin) |
| M28219_at |
LDLR |
15 |
(67–277) |
0.77 |
0.14 |
5.42 |
low density lipoprotein receptor (familial hypercholesterolemia) |
| X68194_at |
SYPL |
5 |
(1915–2089) |
1.67 |
0.31 |
5.42 |
synaptophysin-like protein |
| U85267_at |
DSCR1 |
10 |
(64–169) |
1.20 |
0.24 |
5.08 |
Down syndrome critical region gene 1 |
| L36051_at |
THPO |
6 |
(1647–1809) |
1.05 |
0.21 |
4.96 |
thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) |
|
Number of Affymetrix Probes in the Predicted Pseudo-exon: number of probes that are contained in a predicted alternatively spliced pseudo-exon. Nucleotide Positions of Predicted Pseudo-exon in the Gene: nucleotide positions of the pseudo-exon from the beginning of the gene it resides. Mean difference: Mean difference of the expression values between the two tissue types being compared for each predicted pseudo-exon in the t-test in STEP 2. Standard Error: the standard error calculated in the same t-test. Z-score: the ratio of mean difference over standard error (noise), a measure of significance of the difference between the two tissues being compared. The sign of the Z-scores indicate direction of the difference. A negative Z-score means a lower expression in metastatic medulloblastomas than in non-metastatic medulloblastomas, and vice-versa for a positive Z-score. | |||||||
Fan et al. Theoretical Biology and Medical Modelling 2006 3:19 doi:10.1186/1742-4682-3-19 |
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