Table 2

Mean relative errors (MREs) as a function of experimental errors. The MREs of the S-system models and the original models were measured in case study 2. The time-course data obtained from the models included the perturbation-of-state variable in order to examine the difference in dynamic response between the S-system model and the original Michaelis-Menten model. The Jacobian and steady-state fluxes were reproduced with a 100% numerical error. Numerical errors for the Jacobian were inserted equally into all the elements of the Jacobian. X₁was the target of the perturbation. The time-course data were obtained from the S-system model where X₁was perturbed by an increase of 50%. Ten time points were sampled for the calculation, with an interval of 0.5 s between them. The MRE was calculated from the time-course data in the S-system model and the original Michaelis-Menten model. In the case of the branched biochemical pathway (case study 2), the Jacobian was increased by 100%, and the three steady-state fluxes, J_1–2, J_3–5, and J_4–6represent the flux through V₁ and V₂, the flux through V₃ and V₅ and the flux through V ₄ and V₆, respectively.

Kitayama et al. Theoretical Biology and Medical Modelling 2006 3:24   doi:10.1186/1742-4682-3-24