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Cellular calculus within Nudge++™ |
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| Internal States |
+ |
External Cues |
→ |
Cell Actions |
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| age |
boundaries |
growth |
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| cell-cycle phase |
local position |
division |
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| phase-age |
global position |
movement |
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| generation |
death |
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| clone |
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| lineage |
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Individual model cells evaluate internal states and environmental cues and carry out specific actions based on this evaluation. Additional states, cues and actions other than those listed can be added to each column. A cohort of model cells forms a tissue or organ. Simulations represent the pooled behavior of these cell cohorts over simulated tissue time. Details of these procedures have been presented elsewhere[16]. | ||||
Fisher and Bodenstein Theoretical Biology and Medical Modelling 2006 3:9 doi:10.1186/1742-4682-3-9 |
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