Table 2

Sequential achievement of modeling goals

Simulation I
 Simulation II
 Simulation III
 Simulation IV
 Simulation V

Homogeneous Growth
 Edge Growth
 Edge Growth with Chest Wall Trophism
 Edge Growth with Chest Wall Trophism and Tropism
 Edge Growth with Chest Wall Trophism and Differential Tropism
Development from PPF alone
 +
 +
 +
 +
 +
Non-muscular central tendon
 +
 +
 +
 +
 +
Central before peripheral differentiation
+
 +
 +
 +
Anterior extension along body wall

+/-
 +
 +
Curvilinear morphology of hemidiaphragm


+
 +
Normal anterior diaphragm ipsilateral to CDH


+/-
 +
Posterior PPF persists as large CDH



+

The success of individual simulations in reproducing major observed morphological components of the developing normal and CDH diaphragm are tabulated; (+), component present; (+/-), component partially present.

Fisher and Bodenstein Theoretical Biology and Medical Modelling 2006 3:9   doi:10.1186/1742-4682-3-9