|
Extended E-D model of breast cancer and prostate cancer |
|
| Hormone receptor |
Property |
|
|
|
| Membrane androgen receptor |
↑apoptotic proteins ↓bcl-2 (BC only) ↑bcl-2 (PC only) ↓AS3 ↑Ca++ influx |
|
|
|
| Intracellular androgen receptor |
↓apoptotic proteins ↓bcl-2 ↑AS3 ↓Ca++ influx ↑calreticulin |
|
|
|
| Estrogen receptor-αβ heterodimer |
↑telomerase activity (PC only) |
| Estrogen receptor-α homodimer |
↑telomerase activity |
| Estrogen receptor-α |
↑bcl-2 |
| Estrogen receptor-β |
↓bcl-2 |
| Membrane estrogen receptor |
↑bcl-2 |
| Progesterone receptor A |
↑bcl-2 |
| Progesterone receptor B |
↓bcl-2 |
| Membrane progesterone receptor |
↓bcl-2 |
Friedman Theoretical Biology and Medical Modelling 2007 4:28 doi:10.1186/1742-4682-4-28 |
|