The allosteric modulation of lipases and its possible biological relevance

Jens Köhler and Bernhard Wünsch

Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Hittorfstraße 58-62, D-48149 Münster, Germany

author email corresponding author email

Theoretical Biology and Medical Modelling 2007, 4:34doi:10.1186/1742-4682-4-34


Published:	7 September 2007

Abstract

Background

During the development of an enantioselective synthesis using the lipase from Mucor miehei an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown.

Theory

Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism.

Conclusion

This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.