Table 1

FSC of Selected Proteins

length (aa)
 Number of Sequences
 Null State (Bits)
 FSC (Fits)
 FSC Density Fits/aa
Ankyrin
 33
 1,171
 143
 46
 1.4
HTH 8
 41
 1,610
 177
 76
 1.9
HTH 7
 45
 503
 194
 83
 1.8
HTH 5
 47
 1,317
 203
 80
 1.7
HTH 11
 53
 663
 229
 80
 1.5
HTH 3
 55
 3,319
 238
 80
 1.5
Insulin
 65
 419
 281
 156
 2.4
Ubiquitin
 65
 2,442
 281
 174
 2.7
Kringle domain
 75
 601
 324
 173
 2.3
Phage Integr N-dom
 80
 785
 346
 123
 1.5
VPR
 82
 2,372
 359
 308
 3.7
RVP
 95
 51
 411
 172
 1.8
Acyl-Coa dh N-dom
 103
 1,684
 445
 174
 1.7
MMR HSR1
 119
 792
 514
 179
 1.5
Ribosomal S12
 121
 603
 523
 359
 3.0
FtsH
 133
 456
 575
 216
 1.6
Ribosomal S7
 149
 535
 644
 359
 2.4
P53 DNA domain
 157
 156
 679
 525
 3.3
Vif
 190
 1,982
 821
 675
 3.6
SRP54
 196
 835
 847
 445
 2.3
Ribosomal S2
 197
 605
 851
 462
 2.4
Viral helicase1
 229
 904
 990
 335
 1.5
Beta-lactamase
 239
 1,785
 1,033
 336
 1.4
RecA
 240
 1,553
 1,037
 832
 3.5
Bac luciferase
 272
 1,900
 1,176
 357
 1.3
tRNA-synt 1b
 280
 865
 1,210
 438
 1.6
SecY
 342
 469
 1,478
 688
 2.0
EPSP Synthase
 372
 1,001
 1,608
 688
 1.9
FTHFS
 390
 658
 1,686
 1,144
 2.9
DctM
 407
 682
 1,759
 724
 1.8
Corona S2
 445
 836
 1,923
 1,285
 2.9
Flu PB2
 608
 1,692
 2,628
 2,416
 4.0
Usher
 724
 316
 3,129
 1,296
 1.8
Paramyx RNA Pol
 887
 389
 3,834
 1,886
 2.1
ACR Tran
 949
 1,141
 4,102
 1,650
 1.7
Random sequences
 1000
 500
 4,321
 0
 0
50-mer polyadenosine
 50
 1
 0
 0
 0

Results for 35 protein families Shown above are the 35 protein families analyzed, their sequence length (column 1), the number of sequences analyzed for each family (column 2), the Shannon uncertainty of the Null State Hø (Eqn. 4) for each protein (column 3), the FSC value ζ in Fits for each protein (column 4), and the average Fit value/site (FSC/length, column 5). For comparison, the results for a set of uniformly random amino acid sequences (RSC) are shown in the second from last row, and a highly ordered, 50-mer polyadenosine sequence (OSC) in the last row. All values, except for the OSC example, which was calculated from the constrained ground state required to produce OSC, were computed from the null state. The Fit values obtained can be discussed as the measure of the change in functional uncertainty required to specify any functional sequence that falls into the given family being analyzed.

Durston et al. Theoretical Biology and Medical Modelling 2007 4:47   doi:10.1186/1742-4682-4-47