Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia

Tunahan Çakιr¹ , Selma Alsan¹ , Hale Saybaşιlι² , Ata Akιn² and Kutlu Ö Ülgen¹

¹Department of Chemical Engineering, Boğaziçi University, 34342, Bebek. Istanbul, Turkey

²Institute of Biomedical Engineering, Boğaziçi University, 34342, Bebek. Istanbul, Turkey

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Theoretical Biology and Medical Modelling 2007, 4:48doi:10.1186/1742-4682-4-48


Published:	10 December 2007

Additional file 1:

Reaction Set of Metabolic Reconstruction for Astrocytes and Neurons.

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Additional file 2:

Supplementary Table 1 – Metabolic differences in two cell types reflected in our model.

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Additional file 3:

Employed objective functions with corresponding reasonings.

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Additional file 4:

Supplementary Table 3 – Flux distributions for all reactions in resting and anoxic states.