|
Parameter values that were used in the simulations of the basic model. |
|||
| Parameter |
Description |
Value (units) |
|
|
|
|||
| λ |
Production rate of uninfected cells |
10.0 |
(cells/day) |
| d |
Rate of uninfected cell die-off |
0.1 |
(day-1) |
| β |
Rate infected cells are produced from uninfected cells and free virus |
0.01 |
(virion·day-1) |
| a |
Infected cell death rate (due to virus) |
0.5 |
(day-1) |
| p |
Rate that infected cells are killed by CTLE cells |
1.0 |
(cells/day) |
| b |
Rate that CTLP die-off |
0.001 |
(day-1) |
| q |
Fraction of CTLP cells that proliferate into CTLE cells |
0.1 |
(T-cell/T-cell) |
| h |
Rate of CTLE die-off |
0.1 |
(day-1) |
| k |
Rate at which free virions are produced from infected cells |
3.0 |
(virion·day-1) |
| u |
Viral decay rate |
3.0 |
(day-1) |
|
Simulations were based on values used in Nowak and May [1], Nowak and Bangham [3] and Wodarz and colleagues [4]. Immune responsiveness (ci) and the connectivity coefficient (ωi) were varied throughout this paper. Their specific values for each simulation experiment are described in the Methods section. | |||
Vickers and Osgood Theoretical Biology and Medical Modelling 2007 4:49 doi:10.1186/1742-4682-4-49 |
|||