Table 1

Kinetic equations and initial concentrations. See Table 2 for references.
Reactant	Molecular variable	Initial concentration [nM]	ODE

X₁	EGF	to be varied	d(X₁)/dt = -v₁
X₂	EGFR	80	d(X₂)/dt = -v₁
X₃	EGF-EGFR	0	d(X₃)/dt = v₁- 2v₂
X₄	(EGF-EGFR)2	0	d(X₄)/dt = v₂+ v₄- v₃
X₅	EGF-EGFR-P	0	d(X₅)/dt = v₃+ v₇- v₄- v₅
X₆	PLCγ	10	d(X₆)/dt = v₈- v₅
X₇	EGF-EGFR-PLCγ	0	d(X₇)/dt = v₅- v₆
X₈	EGF-EGFR-PLCγ-P	0	d(X₈)/dt = v₆- v₇
X₉	PLCγ-P	0	d(X₉)/dt = v₇- v₈- v₉- v₁₀
X₁₀	PLCγ-P-I	0	d(X₁₀)/dt = v₉
X₁₁	PKC	10	d(X₁₁)/dt = -v₁₀
X₁₂	PKC*	0	d(X₁₂)/dt = v₁₀- v₁₁
X₁₃	Raf	100	d(X₁₃)/dt = -v₁₁
X₁₄	Raf*	0	d(X₁₄)/dt = v₁₁- v₁₂- v₁₄
X₁₅	MEK	120	d(X₁₅)/dt = v₁₃- v₁₂
X₁₆	MEK-P	0	d(X₁₆)/dt = v₁₂+ v₁₅- v₁₃- v₁₄
X₁₇	MEK-PP	0	d(X₁₇)/dt = v₁₄- v₁₅- v₁₆- v₁₈
X₁₈	ERK	100	d(X₁₈)/dt = v₁₇- v₁₆
X₁₉	ERK-P	0	d(X₁₉)/dt = v₁₆+ v₁₉- v₁₇- v₁₈
X₂₀	ERK-PP	0	d(X₂₀)/dt = v₁₈- v₁₉

- PKC* and Raf * indicate the activated form of PKC and Raf, respectively.
Wang et al. Theoretical Biology and Medical Modelling 2007 4:50 doi:10.1186/1742-4682-4-50