Figure 3.

Graphical Representation of the control logic extracted from the basic science references [24, 26, 27]on Gut Epithelial Barrier Function. General flowchart of the components and mechanisms of TJ protein synthesis and localization, the effects of pro-inflammatory stimulation, and the effects of interventions with ethyl pyruvate and NAD⁺. All labeled boxes correspond to agent or environment state variables within the EBABM. In the actual code of the EBABM there are distinct pathways for the different TJ proteins (not shown here for clarity purposes).