Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling

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Comments(1)

Hirotaka Ando (09 September 2008) Kyorin Pharmaceutical Co., Ltd.

Dear readers,

Equations 2-5 include an incorrect term.

The correct equations are as follows.

Equation 2: dCr/dt = (Qr/Vr)(Ca-Cr/Kp,r)-CLrCa/Vr

Equation 3: dCgi/dt = (Qgi/Vgi)(Ca-Cgi/Kp,gi)-CLgiCa/Vgi

Equation 4: dClung/dt = (Qtot/Vlung)(Cv-Clung/Kp, lung)

Equation 5: dCi/dt = (Qi/Vi)(Ca-Ci/Kp,i)

On behalf of all the authors, I apologise for our error.

We will publish a correction article soon.

Sincerely,

Hirotaka Ando

Competing interests

None declared