Table 1

Pharmacokinetic parameters of various compounds used as inputs for each WBPBPK model simulation
Compound
 Rat
 Human
 References



CLtot
(mL/h/kg)
 CLh
(mL/h/kg)
 CLr
(mL/h/kg)
 CLs
(mL/h/kg)
 T1/2
(h)
 RBa
 fB
 CLtot
(mL/h/kg)
 T1/2
(h)
 RBa
 fB
Tolbutamide
 109
 109
 0
 0
 1.8
 0.75
 0.36
 24.0
 7.0
 0.75
 0.12
 11–13
Diclofenac
 1809
 1176
 633
 0
 0.14
 0.55
 0.009
 447
 1.2
 0.55
 0.009
 12, 14–19
Midazolam
 3024
 1542
 269
 1213
 0.53
 1
 0.066
 473
 2.8
 0.80
 0.043
 12, 20–22
Diazepam
 2492
 2343
 149
 0
 1.1
 1.04
 0.13
 40.4
 32.8
 1.04
 0.03
 12, 23, 24
Phenytoin
 1806
 1246
 181
 379
 0.37
 0.99
 0.23
 187
 13.2
 0.61
 0.20
 11, 12, 14, 25, 26
Imipramine
 2544
 1649
 895
 0
 3.5
 1.67
 0.01
 424
 16.5
 1.67
 0.14
 12, 27–30
Lidocaine
 4252
 1276
 2764
 213
 0.57
 1.27
 0.30
 938
 2.1
 0.80
 0.81
 12, 31–35
Gatifloxacin
 1101
 341
 574
 186
 1.8
 1.07
 0.68
 252
 6.5
 1.07
 0.75
 36
Grepafloxacin
 1079
 917
 151
 11
 3.4
 1.34
 0.44
 245
 11.6
 1.1
 0.45
 37–39
Gemifloxacin
 1300
 163
 599
 432
 1.6
 1
 0.57
 500
 7.0
 1.2
 0.30
 40, 41
Pazufloxacin
 970
 90
 721
 159
 0.88
 1
 0.74
 384
 1.8
 1
 0.77
 38, 42–45
Enoxacin
 1794
 57
 940
 797
 1.8
 0.91
 0.71
 527
 6.0
 0.91
 0.57
 38, 46–48
Fleroxacin
 285
 57
 195
 34
 2.6
 1.29
 0.40
 120
 9.5
 1
 0.77
 36, 38, 49
Lomefloxacin
 1243
 973
 270
 0
 4.0
 1
 0.69
 252
 7.1
 1
 0.79
 50, 51

aRB (blood-plasma concentration ratio) assumed to be 1 when there were no data in the literature.

Ando et al. Theoretical Biology and Medical Modelling 2008 5:19   doi:10.1186/1742-4682-5-19