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Resolution: standard / high Figure 1.
Examples of the three different sampling schemes: (a) random sampling, (b) full factorial sampling, and (c) Latin Hypercube Sampling, for a simple case of 10 samples (samples for τ2 ~ U (6,10) and λ ~ N (0.4, 0.1) are shown). In random sampling, there are regions of the parameter space that are not sampled and other regions that are heavily sampled; in full factorial sampling, a random value is chosen in each interval for each parameter and every possible combination of parameter values is chosen; in Latin Hypercube Sampling, a value is chosen once and only once from every interval of every parameter (it is efficient and adequately samples the entire parameter space).
Hoare et al. Theoretical Biology and Medical Modelling 2008 5:4 doi:10.1186/1742-4682-5-4 |