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The MLEs of the model parameters and the QTL position derived from 200 simulation replicates assuming no imprinting. The square root of the mean square errors (RMSEs) of the MLEs are given in parentheses. |
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| QMQP |
QMqP |
qMQP |
qMqP |
Residual |
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|
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| H2 |
n |
Position (cM) |
α1 36.5 |
β1 6.5 |
γ1 0.7 |
α2 35 |
β2 6 |
γ2 0.7 |
α3 35 |
β3 6 |
γ3 0.7 |
α4 33.5 |
β4 5.5 |
γ4 0.7 |
σ2 |
ρ 0.8 |
|
|
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| 0.1 |
200 |
45.24 (4.351) |
36.74 (0.397) |
6.53 (0.096) |
0.698 (0.006) |
35.09 (0.765) |
5.99 (0.188) |
0.70 (0.013) |
35.35 (0.855) |
6.09 (0.204) |
0.70 (0.014) |
33.71 (0.379) |
5.54 (0.090) |
0.70 (0.007) |
0.004 (0.0009) |
0.80 (0.02) |
| 0.1 |
500 |
46.01 (2.196) |
36.74 (0.327) |
6.54 (0.070) |
0.70 (0.004) |
35.17 (0.567) |
6.00 (0.138) |
0.70 (0.012) |
35.28 (0.640) |
6.07 (0.160) |
0.70 (0.012) |
33.69 (0.273) |
5.53 (0.058) |
0.70 (0.004) |
0.004 (0.0004) |
0.80 (0.01) |
| 0.4 |
200 |
46.07 (1.731) |
36.56 (0.137) |
6.51 (0.037) |
0.70 (0.002) |
34.99 (0.304) |
6.00 (0.076) |
0.70 (0.005) |
35.11 (0318) |
6.02 (0.076) |
0.70 (0.005) |
33.55 (0.127) |
5.51 (0.033) |
0.70 (0.003) |
0.001 (0.0005) |
0.80 (0.011) |
| 0.4 |
500 |
46.17 (1.07) |
36.56 (0.106) |
6.51 (0.026) |
0.70 (0.002) |
35.03 (0.208) |
6.00 (0.053) |
0.70 (0.004) |
35.07 (0.222) |
6.01 (0.056) |
0.70 (0.004) |
33.54 (0.088) |
5.51 (0.021) |
0.70 (0.002) |
0.0007 (0.0001) |
0.80 (0.005) |
|
The location of the simulated QTL is described by the map distances (in cM) from the first marker of the linkage group (100 cM long). The hypothesized σ2 value is 0.0041 for H2 = 0.10 and 0.0007 for H2 = 0.4. | ||||||||||||||||
Cui et al. Theoretical Biology and Medical Modelling 2008 5:6 doi:10.1186/1742-4682-5-6 |
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