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Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b.

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Theor Biol Med Model. 2006 Jan 10;3:1.

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PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin.

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Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity.

Schupp M, Janke J, Clasen R, Unger T, Kintscher U.

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Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma.

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Molecular activation of PPARgamma by angiotensin II type 1-receptor antagonists.

Erbe DV, Gartrell K, Zhang YL, Suri V, Kirincich SJ, Will S, Perreault M, Wang S, Tobin JF.

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Inhibition of cardiovascular cell proliferation by angiotensin receptor blockers: are all molecules the same?

Benson SC, Iguchi R, Ho CI, Yamamoto K, Kurtz TW.

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Telmisartan, an angiotensin II type 1 receptor blocker, inhibits advanced glycation end-product (AGE)-induced monocyte chemoattractant protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome proliferator-activated receptor-gamma activation.

Matsui T, Yamagishi S, Ueda S, Nakamura K, Imaizumi T, Takeuchi M, Inoue H.

J Int Med Res. 2007 Jul-Aug;35(4):482-9.

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Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway.

Sugimoto K, Kazdová L, Qi NR, Hyakukoku M, Kren V, Simáková M, Zídek V, Kurtz TW, Pravenec M.

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Inhibitory effects of angiotensin receptor blockers on CYP2C9 activity in human liver microsomes.

Kamiyama E, Yoshigae Y, Kasuya A, Takei M, Kurihara A, Ikeda T.

Drug Metab Pharmacokinet. 2007 Aug;22(4):267-75.

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Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma.

Walcher D, Hess K, Heinz P, Petscher K, Vasic D, Kintscher U, Clemenz M, Hartge M, Raps K, Hombach V, Marx N.

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Telmisartan is a potent target for prevention and treatment in human prostate cancer.

Funao K, Matsuyama M, Kawahito Y, Sano H, Chargui J, Touraine JL, Nakatani T, Yoshimura R.

Oncol Rep. 2008 Aug;20(2):295-300.

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Regulation of prostate cancer cell growth and PSA expression by angiotensin II receptor blocker with peroxisome proliferator-activated receptor gamma ligand like action.

Ishiguro H, Ishiguro Y, Kubota Y, Uemura H.

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Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation.

Janke J, Schupp M, Engeli S, Gorzelniak K, Boschmann M, Sauma L, Nystrom FH, Jordan J, Luft FC, Sharma AM.

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Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity.

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Molecular characterisation of the interactions between olmesartan and telmisartan and the human angiotensin II AT1 receptor.

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Br J Pharmacol. 2007 Aug;151(7):952-62. Epub 2007 Jun 18.

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